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A Call for Matching Donors for the LEV Foundation " Robust Mouse Rejuvenation 2 " Fundraiser
The Longevity Escape Velocity (LEV) Foundation was founded by Aubrey de Grey to address an important missing aspect of the ongoing work to produce treatments that target the underlying mechanisms of aging. While the research and development community has made sizable strides in the past decade, and the first rejuvenation therapies now exist in at least prototype form, it remains the case that next to no-one is conducting combination studies that use two or more of these interventions. When considering therapies that can repair forms of the cell and tissue damage that cause aging, it seems plausible that two different thera...
Source: Fight Aging! - September 22, 2023 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
Non-surgical management in children with non-refluxing primary megaureter: a systematic review and meta-analysis
ConclusionsThe low pooled prevalence of secondary surgical intervention and high pooled prevalence of resolution may support the current non-surgical management in children with non-refluxing primary megaureter. However, these results should be interpreted cautiously due to the limited available body of evidence. Future studies should overcome existing limitations of imaging methods by using standardized, comparable criteria and report outcome parameters in a quantitative manner. This would allow more sufficient data synthesis to provide evidence-based recommendations for clinical decision-making and counseling.Systematic ...
Source: Pediatric Nephrology - September 22, 2023 Category: Urology & Nephrology Source Type: research
Effect of robotic-assisted gait training on gait and motor function in spinal cord injury: a protocol of a systematic review with meta-analysis
Introduction
Robotic-assisted gait training (RAGT) has been reported to be effective in rehabilitating patients with spinal cord injury (SCI). However, studies on RAGT showed different results due to a varied number of samples. Thus, summarising studies based on robotic-related factors is critical for the accurate estimation of the effects of RAGT on SCI. This work aims to search for strong evidence showing that using RAGT is effective in treating SCI and analyse the deficiencies of current studies.
Methods and analysis
The following publication databases were electronically searched in December 2022 without restrictions ...
Source: BMJ Open - September 22, 2023 Category: General Medicine Authors: Wang, L., Peng, J.-l., Chen, A.-l. Tags: Open access, Rehabilitation medicine Source Type: research
Clinical outcomes of ramucirumab plus docetaxel in the treatment of patients with non-small cell lung cancer after immunotherapy: a systematic literature review
CONCLUSIONS: Cumulatively, these results support the combination of ramucirumab plus docetaxel as an effective and safe subsequent therapy for the treatment of patients with metastatic NSCLC with disease progression irrespective of previous ICI treatment.PMID:37731641 | PMC:PMC10507469 | DOI:10.3389/fonc.2023.1247879
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Edward B Garon Carla Visseren-Grul Maria Teresa Rizzo Tarun Puri Suresh Chenji Martin Reck Source Type: research
Are you thinking what I'm thinking? Defining what we mean by "polysubstance use."
Am J Drug Alcohol Abuse. 2023 Sep 21:1-7. doi: 10.1080/00952990.2023.2248360. Online ahead of print.ABSTRACTThe rise in drug overdoses and harms associated with the use of more than one substance has led to increased use of the term "polysubstance use" among researchers, clinicians, and public health officials. However, the term retains no consistent definition across contexts. The current authors convened from disciplines including sociology, epidemiology, neuroscience, and addiction psychiatry to propose a recommended definition of polysubstance use. An iterative process considered authors' formal and informal conversati...
Source: The American Journal of Drug and Alcohol Abuse - September 21, 2023 Category: Addiction Authors: Amanda M Bunting Riley Shearer Ashley N Linden-Carmichael Arthur Robin Williams Sandra D Comer Magdalena Cerd á Jennifer Lorvick Source Type: research
Social participation in evidence: the memorable 17th National Health Conference
Cad Saude Publica. 2023 Sep 18;39(9):e00154023. doi: 10.1590/0102-311XPT154023. eCollection 2023.NO ABSTRACTPMID:37729307 | DOI:10.1590/0102-311XPT154023
Source: Cadernos de Saude Publica - September 20, 2023 Category: International Medicine & Public Health Authors: Claudia Travassos Luciana Dias de Lima Source Type: research
Psychosocial interventions and their effectiveness on quality of life among elderly persons living with HIV in Africa South of the Sahara: Systematic review and meta -analysis protocol
by Marijanatu Abdulai, David Owiredu, Isaac Boadu, Philip Teg-Nefaah Tabong, Bismark Sarfo, Harriet Affran Bonful, Adolphina Addo- Lartey, Kwadwo Owusu Akuffo, Anthony Danso-Appiah
BackgroundThe number of elderly people living with HIV (EPLHIV) has increased significantly as a result of antiretroviral treatment (ART) and this has brought about a variety of psychosocial challenges that have an impact on their quality of life (QoL). Various psychosocial interventions have been tried or implemented in Sub-Saharan Africa (SSA) to improve QoL of EPLHIV. However, there is paucity of data on the types and effectiveness of these i...
Source: PLoS One - September 20, 2023 Category: Biomedical Science Authors: Marijanatu Abdulai Source Type: research
Exploring experiences of times without care and encounters in dementia: protocol for a living and adaptive evidence map
Introduction
Individuals with dementia spend most of the day without care, without encounters, and usually without activity. Although this has been proven in studies, there is a knowledge gap on how individuals with dementia experience these periods of time. Such knowledge would be highly relevant for health professionals and relatives to develop adequate strategies for dealing with these periods of time. The FreiZeit study aims to reconstruct periods of time without care and encounters from the perspective of individuals with dementia and formal and informal carers. The specific objective of this review is to provide a co...
Source: BMJ Open - September 20, 2023 Category: General Medicine Authors: Hirt, J., Adlbrecht, L., Maurer, C., Beer, T. Tags: Open access, Public health Source Type: research
Mapping global evidence on injuries/trauma due to sexual and gender-based violence for research prioritisation and development of guidelines to mitigate their impact: a scoping review protocol
This study will include evidence sources focused on the epidemiological burden, guidelines for out-of-hospital and in-hospital care of victims, barriers or facilitators to reporting and obtaining healthcare, and approaches for mitigating injuries/trauma due to SGBV. The search will be limited to publications within 10 ye ars (2012 to 2023). Two authors will apply the eligibility criteria to identify potentially relevant citations. The data will be extracted in duplicate and methodological quality assessed using varied tools (Mixed Method Quality Appraisal Tool; and Appraisal of Guidelines, Research and Evaluation in strum...
Source: Systematic Reviews - September 20, 2023 Category: International Medicine & Public Health Source Type: research
Transdiagnostic MRI markers of psychopathology following traumatic brain injury: a systematic review and network meta-analysis protocol
Introduction
Psychopathology following traumatic brain injury (TBI) is a common and debilitating consequence that is often associated with reduced functional and psychosocial outcomes. There is a lack of evidence regarding the neural underpinnings of psychopathology following TBI, and whether there may be transdiagnostic neural markers that are shared across traditional psychiatric diagnoses. The aim of this systematic review and meta-analysis is to examine the association of MRI-derived markers of brain structure and function with both transdiagnostic and specific psychopathology following moderate–severe TBI.
Meth...
Source: BMJ Open - September 19, 2023 Category: General Medicine Authors: Samiotis, A., Hicks, A. J., Ponsford, J., Spitz, G. Tags: Open access, Radiology and imaging Source Type: research
Robotic-assisted versus laparoscopic incisional hernia repair: a systematic review and meta-analysis
ConclusionThe robotic approach for incisional hernia repair was associated with a significant difference between the two groups in complications and recurrence rates, a longer operative time than laparoscopic repair, but with a shorter length of stay.
Source: Hernia - September 19, 2023 Category: Sports Medicine Source Type: research
Methodology to predict strain of bridging vein due to rotation of head - Takahashi Y, Yanaoka T.
27th International Technical Conference on the Enhanced Safety of Vehicles (ESV): Enhanced and Equitable Vehicle Safety for All: Toward the Next 50 Years
https://www-esv.nhtsa.dot.gov/Proceedings/27/27ESV-000261.pdf
The brain stem can be damaged by...
Source: SafetyLit - September 18, 2023 Category: International Medicine & Public Health Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news
Fall Activities for NIGMS Trainees
Welcome to the NIGMS Feedback Loop! As a current NIGMS trainee, you’re automatically subscribed to our blog so that we can provide you with information about upcoming meetings and events, opportunities to provide your input, program news, and more.
As the school yearbegins, we’d like to start by sharing upcoming NIGMS-supported events you can participate in.
We’re holding our annual Judith H. Greenberg Early Career Investigator Lecture virtually and on the NIH campus in Bethesda, Maryland, on September 27. The speaker is Akhila Rajan, Ph.D., from the Fred Hutchinson Cancer Center, and she’ll describe her ...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - September 18, 2023 Category: Biomedical Science Authors: Chrissa Chverchko Tags: NIGMS Trainee Community Source Type: blogs
Ensuring Fairness in Medical Education Assessment
This study takes a first step in centering the margins as we as medical educators grow our understanding of the dynamics of promoting fairness in assessment. Future studies should explore feedback with intentional inclusion and involvement of diverse students, teachers, and researchers at every stage of the research process from conceptualization through dissemination and application of the new learning. We thank our participants for their time and candor discussing this sensitive topic and the Group on Educational Affairs for funding our work. Thank you for your time and attention and the focus that you’ll put on th...
Source: Academic Medicine Blog - September 18, 2023 Category: Universities & Medical Training Authors: amrounds Tags: AM Podcast AM Podcast Transcript Academic Medicine podcast assessment equity Macy Foundation medical education Source Type: blogs
